{"id":1735,"date":"2025-07-30T13:31:29","date_gmt":"2025-07-30T04:31:29","guid":{"rendered":"https:\/\/www.kr-geninus.com\/?p=1735"},"modified":"2025-07-30T13:41:21","modified_gmt":"2025-07-30T04:41:21","slug":"2025-07-26-geninus-featured-in-nature-communications","status":"publish","type":"post","link":"https:\/\/www.kr-geninus.com\/?p=1735","title":{"rendered":"[2025\/07\/26] Geninus Featured in Nature Communications"},"content":{"rendered":"<p><strong>[2025\/07\/26] Geninus Featured in Nature Communications<\/strong><\/p>\n<p><strong>[July 26, 2025] \u201cSpatial Omics Study by Geninus CEO Published in<\/strong> <em><strong>Nature Communications<\/strong><\/em>\u201d<\/p>\n<p>A study led by Geninus CEO Dr. Woong-Yang Park has been published in <strong><em>Nature Communications<\/em><\/strong>, focusing on host immune response mechanisms against nontuberculous mycobacterial (NTM) pulmonary infections.Dr. Park served as the corresponding author. Prof. <em><strong>Eun-Kyeong Jo<\/strong><\/em> of Chungnam National University was co-senior author, and <strong><em>Yeon-Ju Lee<\/em><\/strong> contributed as a co-first author.<\/p>\n<p><strong>Study Overview<\/strong><br \/>\nThe study investigated the critical role of ATG7 in innate immune cells in defending against NTM infections, using spatial transcriptomics and in vivo\/in vitro models. Key findings include:<\/p>\n<ul>\n<li>\u30fbReduced ATG7 expression in immune cells of NTM patients<\/li>\n<li>\u30fbElevated bacterial burden and pathological inflammation in ATG7-deficient models<\/li>\n<li>\u30fbNeutrophil-driven immune dysregulation and cell death<\/li>\n<li>\u30fbImpaired phagolysosomal fusion and mitochondrial stress in ATG7-deficient macrophages<\/li>\n<\/ul>\n<p>These insights advance our understanding of immune regulation and may guide future therapeutic strategies for NTM lung disease.<\/p>\n<p><strong>Publication Info<\/strong><br \/>\n<strong>Title: <em>ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections<\/em><\/strong><br \/>\n<strong>Journal: <em>Nature Communications<\/em><\/strong> (2025)<\/p>\n<p>\ud83d\udd17 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-61791-1#author-information\" target=\"_new\" rel=\"noopener\">Read the full article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>[2025\/07\/26] Geninus Featured in Nature Communications [July 26, 2025] \u201cSpatial Omics Study by Geninus CEO Published in Nature Communications\u201d A study led by Geninus CEO Dr. Woong-Yang Park has been published in Nature Communications, focusing on host immune response mechanisms against nontuberculous mycobacterial (NTM) pulmonary infections.Dr. Park served as the corresponding author. Prof. Eun-Kyeong Jo [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[37],"tags":[],"class_list":["post-1735","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=\/wp\/v2\/posts\/1735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1735"}],"version-history":[{"count":5,"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=\/wp\/v2\/posts\/1735\/revisions"}],"predecessor-version":[{"id":1742,"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=\/wp\/v2\/posts\/1735\/revisions\/1742"}],"wp:attachment":[{"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.kr-geninus.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}